Biophysics Core

About Me

I earned my PhD from the University of Chinese Academy of Sciences, where I trained in nuclear magnetic resonance (NMR), and completed postdoctoral research at the University of Michigan, Ann Arbor. I now direct the Biophysics Core at the School of Life Science and Technology, ShanghaiTech University, while pursuing independent research.

With a background in physics and biology and over 15 years of experience in NMR, I develop and apply solution- and solid-state NMR methods to investigate the structure and dynamics of biomolecules, supramolecular assemblies, polymers, and functional materials. By combining NMR with AI-driven biophysical approaches, I aim to understand how molecular structure and motion shape the behavior of living systems and materials.

Education & Training

  • Postdoctoral Training

    University of Michigan, Ann Arbor

    Advisor: Ayyalusamy (Rams) Ramamoorthy

  • PhD · Radio Physics and Analytical Chemistry

    University of Chinese Academy of Sciences

    Advisor: Jiwen Feng

  • BS · Physics

    Huazhong University of Science and Technology

Academic Experience

  • Researcher · ShanghaiTech University

    Head of Biophysics Core

Research Interests

  • Solution- and solid-state NMR methods

    Develop and adapt NMR methods for studying complex molecular systems, with an emphasis on sensitivity, resolution, and reliable structural information.

  • Ultrafast MAS and proton-detected NMR

    Advance high-resolution proton detection under ultrafast magic-angle spinning to investigate challenging samples and make more information accessible from small amounts of material.

  • Biomolecular structure and dynamics

    Use NMR to examine how biomolecules are organized and how they move, connecting molecular structure and dynamics with biological function.

  • Supramolecular assemblies and functional materials

    Investigate molecular interactions, assembly, and motion in polymers, supramolecular systems, and functional materials using complementary NMR approaches.

  • AI-assisted biophysical analysis

    Explore ways to combine NMR measurements with AI-based analysis to extract structural and dynamic insights into living systems and materials.

Selected Publications

  1. Robust Heteronuclear Correlations for Sub-milligram Protein in Ultrafast Magic-Angle Spinning Solid-State NMR

    Hang Xiao#, Jian Wang#, Huan Tan, Yuefang Gan, Wenjing Liu, Yan Zhang, Zhengfeng Zhang*, Jun Yang*.

    J. Am. Chem. Soc. 147, 6384-6389 (2025).DOI: 10.1021/jacs.5c00191 ↗

  2. UCl3-Type Crystalline Oxychloride Electrolytes for All-Solid-State Lithium-Ion Batteries

    Junlong Yang, Shiwei Chen, Qiong Yuan, Guangsu Tan, Qinzhe Liu, Shaoyu Yang, Yanxin Deng, Yingbo Zhao, Wei Liu, Yi Yu, Yanming Cui, Jian Wang*, Shou-Hang Bo*, Chao Xu*.

    J. Am. Chem. Soc. 147, 36557-36569 (2025).DOI: 10.1021/jacs.5c11480 ↗

  3. The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1/RIPK3 complex

    Jing Liu, Xia-lian Wu, Jing Zhang, Bing Li, Hua-yi Wang, Jian Wang* & Jun-xia Lu*.

    Nat. Commun. 15, 6975 (2024).DOI: 10.1038/s41467-024-51303-y ↗

View all publications